MAG or myelin-associated glycoprotein is a type one transmembrane protein localized in Schwann cell and oligodendrocyte membranes. This protein is involved during nerve regeneration in PNS. Boster Bio Antibody and ELISA supplies kits for detecting and quantifying this vital protein.
What does Myelin Associated Glycoprotein do in the body?
MAG is crucial to the formation of myelin sheaths. The protein is localized in the inner membrane and interacts with the proteins that attach to the sheath in the axon.
In the central nervous system, where axons do not regenerate in the same way as in the peripheral nervous system, MAG is one of three major healing proteins. The compound inhibits neurogeneration through the binding of NGR.
How does MAG work?
MAG has five immunoglobulin domains and a homodimeric arrangement involving the membrane-proximal domains LG4 and LG5. The protein engages axonal gangliosides at domain LG1.
This molecule is a 100 KDA glycoprotein in complete transmembrane form when uncleaved. The protein acts in signaling and adhesion.
Which diseases is myelin-associated glycoprotein associated with?
The myelin sheath is a protective covering surrounding the axons. Myelin protects and insulates this part of the nerve, enhancing the transmission of electrical impulses.
Disorders surrounding damage to the protective coating, demyelination, relate to MAG. When demyelination occurs, neurological problems often follow resulting in diseases such as multiple sclerosis. Vision loss, muscle spasms and stiffness, loss of coordination, pain and other symptoms are common.
Viruses and MAG
Certain viruses attack the nervous system and limit the presence of myelin-associated glycoprotein. Herpes Simplex and the varicella-zoster virus are prevalent diseases causing damage to this system. They impair the functioning of the protein.
Sialic acids on varicella-zoster virus cells interact with MAG through VZV glycoprotein B to mediate membrane fusion during entry to host cells. Researchers discovered a crucial link between the sialic-acid on the VZV glycoprotein B is essential along with MAG in the process.
Researchers and scientists use ELISA kits to determine the presence of proteins, viruses, and compounds. The plate-based array is highly successful with an accuracy rate near 100 percent.
While false positives and false negatives are possible, they are often related to improper laboratory procedures or an ineffective inoculation period. For this reason, the western blot test is among the most popular methods for finding and quantifying MAG.
Are ELISA Kits accurate?
These kits are accurate. Research shows that they work in 99.9 percent of tests.
Human and other errors can still occur. Proper procedures are necessary for any experiment.
Where can I find MAG ELISA kits?
Researchers and scientists trusted Boster Bio Antibody and ELISA in over 23000 publications and counting. We produce antibodies and kits for study and manufacturing. Our high-quality ELISA sets are available quickly with next day shipping on select items.
A MAG ELISA hit helps you find and quantify this crucial protein for the nervous system. When you are working on a project, visit our website for deals on a variety of kits for human, rat, and mice cells.